Basic
Research
There are
over 300,000 scientists
worldwide pursuing DNA sequencing in academic, research and government
institutions. Scientists use DNA sequencing to discover and analyze new
organisms, identify and determine the function of genes and non-coding
regions
of DNA and gain a better understanding of the causes for genetic
disease. With
the availability
of IBS’s new technology, many RNA expression profiling and DNA
mutation studies which are currently using more cost effective
non-sequencing
methods will be done using sequencing, as sequencing generates for more
detailed
and precise data.
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DNA
Resequencing and Clinical Requirements
Over the past 25 years, DNA sequencing has been dominated by
researchers discovering organisms sequence for the first time ( de novo).
The market is now shifting where most sequencing being done is so
called "resequencing" wherein the nominal sequence of an organism is
know, and variations of that sequence are determined. Nearly all
clinical and
diagnostic applications are resequencing applications as well. For
these types of applicaiotns, the importance shifrs from cost per base
to acombination of failsafe precision, fast test time and low cost
per test. Click here for a
description of the technology.
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Clinical Applications
The IBS sequencing technology is uniquely able to addresst the
requirements of the clinic.The MINI instrument features 20 individual
sample run capability with trandom access and costs a fraction of other
high-throughput sequencers cost. The test time for producing
high-quallity results is hours rather than days and the accuracy is
extremely high
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Cancer
 There
are
about 22 million cancer patients worldwide, including 4 million in the US, 10 million
in Europe, 3
million in India and 2
million in China. The rate of
incidence is expected to grow from 10
million per year to over 15 million per year over the next 20 years. The mutations
in individuals’ genomes which can
lead to cancer are so diverse, that many researchers believe that we
will have
to sequence a patient’s tumor DNA before we can effectively treat his
disease. The NCI has initiated the
Cancer Genome Anatomy project to better understand the variations and
expression characteristics of cancer cells.
HIV/AIDS
Modern
AIDS is caused by the simultaneous infection of a number of HIV
virus mutants, many of which are resistant to the common AIDS drugs.
Sequencing based drug-resistance testing has become a standard of care,
however, current sequencing technoolgy does not have the appropriate
throughput to measure low population mutants.
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