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The Most Flexible Benchtop Sequencing



The new benchtop sequencing system, based on IBS proprietary, patented DNA sequencing by synthesis technology, is capable of running up to 20 individual flow cells in parallel.
IBS Sequencing By Synthesis Technology

Breakthrough Process
IBS has a proprietary, patented DNA sequencing by synthesis (SBS) technology (see our founder's PNAS article) capable of reading out the sequence of DNA with very a high precision, rapid pace and low cost.  Speed and cost advantages come through the ability to sequence billions of samples in parallel on a single chip. The technology incorporates unique advances in DNA sequence readout and DNA sample preparation enabling the development of a very low cost, high throughput system. The technology overcomes the limited throughput and high costs of conventional electrophoretic technologies and most deficiencies of other new generation non-electrophoresis-based sequencing methods.

Three Step SBS Process.

In this process the DNA is first broken into fragments, amplified, attached to a DNA sequence primer, then affixed as a high-density array of spots onto a glass chip. To read out the sequence of each of the spots, the array of fragments is first subjected to reagents containing uniquely engineered DNA bases that include a removable fluorescent dye and an end cap.  These bases attach themselves (Extend) to the end of the growing strand of DNA in accordance with the base on the complementary strand.  The array is scanned by a high-resolution electronic camera (Measure) and the fluorescent output of each of four dye colors at each array position is measured and recorded. The color indicates which base (A, C, G or T) was just incorporated in the DNA fragment in the previous step.  Finally, the array is exposed to cleavage chemistry (Cleave) to break off the fluorescent dye and end cap that will now allow additional bases to be added. The Extend, Measure and Cleave cycle is then repeated.

Digital Sequence Readout

Sequencing results using proprietary four color DNA nucleotides